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Phenacetin (/ f ɪ ˈ n æ s ɪ t ɪ n / ⓘ; acetophenetidin, N-(4-ethoxyphenyl)acetamide [1]) is a pain-relieving and fever-reducing drug, which was widely used following its introduction in 1887. It was withdrawn from medicinal use as dangerous from the 1970s (e.g., withdrawn in Canada in 1973, [2] and by the U.S. Food and Drug ...
Trademarked in 1918, Anacin is one of the oldest brands of pain relievers in the United States. It originally contained acetophenetidin (phenacetin) and was promoted as "aspirin-free relief," but was reformulated in the 1980s following the FDA's ruling to withdraw phenacetin from the market in 1983 due to concerns over its carcinogenic ...
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Another example is Bex, a once popular Australian compound analgesic which is no longer sold. It contained 42% aspirin, 42% phenacetin, plus caffeine. [2]The United States Food and Drug Administration also now requires that manufacturers of compound analgesics unequivocally state each ingredient's purpose.
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It is also used as a chemical intermediate in the manufacture of bucetin, phenacetin, ethoxyquin, and phenacaine. p-Phenetidine has high renal toxicity [3] and it is believed to be responsible for the adverse effects that led to the withdrawal of phenacetin and bucetin from pharmaceutical use. p-Phenetidine is also a possible mutagen. [4]
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