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THC was reported to have a fast initial half-life of 6 minutes and a long terminal half-life of 22 hours in a population pharmacokinetic study. [23] [33] Conversely, the Food and Drug Administration label for dronabinol reports an initial half-life of 4 hours and a terminal half-life of 25 to 36 hours. [22]
Like Δ 9-THC, 11-hydroxy-THC is a partial agonist at the cannabinoid receptor CB 1, but with significantly higher binding affinity (K i = 0.37 nM compared to Δ 9-THC K i = 35 nM). [7] With respect to cAMP inhibition at CB 1 it displays a similar efficacy to that of Δ 9 -THC (EC 50 = 11 nM vs. EC 50 = 5.2 nM, respectively), but a lower ...
11-COOH-THC is a Schedule 8 prohibited substance in Western Australia under the Poisons Standard (July 2016). [15] A schedule 8 substance is a controlled Drug – Substances which should be available for use but require restriction of manufacture, supply, distribution, possession and use to reduce abuse, misuse and physical or psychological dependence.
Most cannabinoids are lipophilic (fat soluble) compounds that easily store in fat, thus yielding a long elimination half-life relative to other recreational drugs. [1] Metabolites of cannabis are usually detectable in urine drug tests from 3 days up to 10 days according to Redwood Laboratories; heavy users can produce positive tests for 30 days ...
The terminal half-life of THC is 25 to 36 hours, [68] whereas for CBD it is 18 to 32 hours. [67] CBD is hydroxylated by P450 liver enzymes into 7-OH-CBD. Its metabolites are products of primarily CYP2C19 and CYP3A4 activity, with potential activity of CYP1A1, CYP1A2, CYP2C9, and CYP2D6. [69]
Since it has a longer side chain, its cannabinoid effects are "far higher than Δ 9-THC itself." Tetrahydrocannabiphorol has a reported binding affinity of 1.2 nM at CB 1, approximately 33 times that of Δ 9-THC (40 nM at CB 1). [4] THCP was studied by Roger Adams as early as 1942. [5]
Similarly to THC, it has 7 double bond isomers and 30 stereoisomers. [6] The Δ 8 isomer is known as a synthetic cannabinoid under the code name JWH-130, [7] and the ring-opened analogue cannibidibutol (CBDB) is also known. [8] THC-Butyl can be synthesized from 4-butylresorcinol. [citation needed] Cannabidibutol (CBDB), 60113-11-3
The 8β enantiomer retains psychoactive effects in animal studies with only slightly lower potency than THC, while the 8α enantiomer is much weaker. Both enantiomers have a shorter half-life in the body than 11-hydroxy-THC , making 8,11-dihydroxy-THC potentially useful for drug testing to distinguish between recent cannabis use and use longer ...