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Metabolic bone disease is an abnormality of bones caused by a broad spectrum of disorders. Most commonly these disorders are caused by deficiencies of minerals such as calcium, phosphorus, magnesium or vitamin D leading to dramatic clinical disorders that are commonly reversible once the underlying defect has been treated.
A bone disease is also called an "osteopathy", but because the term osteopathy is often used to refer to an alternative health-care philosophy, use of the term can cause some confusion. [ 2 ] Bone and cartilage disorders
Hypophosphatasia (/ ˌ h aɪ p oʊ ˈ f ɒ s f eɪ t ˌ eɪ ʒ ə /; also called deficiency of alkaline phosphatase, phosphoethanolaminuria, [5] or Rathbun's syndrome; [1] sometimes abbreviated HPP [6]) is a rare, and sometimes fatal, inherited [7] metabolic bone disease. [8]
The impairment of bone metabolism causes inadequate bone mineralization. Osteomalacia in children is known as rickets, and because of this, use of the term "osteomalacia" is often restricted to the milder, adult form of the disease. Signs and symptoms can include diffuse body pains, muscle weakness, and fragility of the bones.
The journal has its origins in several journals which merged. Metabolic Bone Disease and Related Research was established in 1978, with a different ISSN. [1] [2]According to the IBMS website, two scientific journals, Bone [3] (with the same ISSN as this journal; 1985 onwards) [4] and Bone and Mineral [5] [6] [a] merged under the title Bone, which became the official journal of IBMS, published ...
The Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism is a resource for scientists and students seeking an overview of the bone and mineral field and for clinicians who see patients with disorders of bone and mineral metabolism. The text provides valuable information on the symptoms, pathophysiology, diagnosis, and ...
Renal osteodystrophy is defined as an alteration of bone in patients with chronic kidney disease (CKD). [1] It is one measure of the skeletal component of the systemic disorder of chronic kidney disease-mineral and bone disorder (CKD-MBD).
Paget's disease of bone is the second most common metabolic bone disorder, after osteoporosis. [37] The overall prevalence and severity of Paget's disease are decreasing; the cause for these changes is unclear. [38] Paget's disease is rare in people less than 55 years of age, [7] and the prevalence increases with age. [38]