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A repressor that binds with a co-repressor is termed an aporepressor or inactive repressor. One type of aporepressor is the trp repressor , an important metabolic protein in bacteria. The above mechanism of repression is a type of a feedback mechanism because it only allows transcription to occur if a certain condition is present: the presence ...
The repressor gene, lacI, will produce the repressor protein LacI which is under allosteric regulation. These genes are activated by the presence of lactose in the cell which acts as an effector molecule that binds to LacI. When the repressor is bound to lactose, it will not bind to the operator, which allows RNA polymerase to bind to the ...
In the study, Elowitz and Leibler generated figures showing oscillations of repressor proteins, using integration and typical parameter values as well as a stochastic version of the repressilator model using similar parameters. These models were analyzed to determine the values of various rates that would yield a sustained oscillation.
In genetics and molecular biology, a corepressor is a molecule that represses the expression of genes. [1] In prokaryotes, corepressors are small molecules whereas in eukaryotes, corepressors are proteins. A corepressor does not directly bind to DNA, but instead indirectly regulates gene expression by binding to repressors.
Tet Repressor proteins (otherwise known as TetR) are proteins playing an important role in conferring antibiotic resistance to large categories of bacterial species. Tetracycline (Tc) is a broad family of antibiotics to which bacteria have evolved resistance. Tc normally kills bacteria by binding to the bacterial ribosome and halting protein ...
RE1-Silencing Transcription factor (REST), also known as Neuron-Restrictive Silencer Factor (NRSF), is a protein which in humans is encoded by the REST gene, and acts as a transcriptional repressor. [5] [6] [7] REST is expressly involved in the repression of neural genes in non-neuronal cells.
In molecular biology and genetics, transcription coregulators are proteins that interact with transcription factors to either activate or repress the transcription of specific genes. [1] Transcription coregulators that activate gene transcription are referred to as coactivators while those that repress are known as corepressors .
The system involves the RecA protein (Rad51 in eukaryotes). The RecA protein, stimulated by single-stranded DNA, is involved in the inactivation of the repressor of SOS response genes thereby inducing the response. It is an error-prone repair system that contributes significantly to DNA changes observed in a wide range of species.