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[1] [3] Other forms of statin associated muscle damage usually resolve after stopping the involved statin. [1] Mild joint pain and rash may be present. [3] In people affected by SAAM, the median duration of statin therapy was 38 months before the onset of muscular symptoms. [4] SAAM may affect people after long-term statin use even if they had ...
Side effects of statins include muscle pain, increased risk of diabetes, and abnormal blood levels of certain liver enzymes. [5] Additionally, they have rare but severe adverse effects, particularly muscle damage, and very rarely rhabdomyolysis. [6] [7]
Common types of myopathy due to statins include myalgia, myositis, and rhabdomyolysis. Statins induce myopathy by inhibiting protein synthesis within the muscle. [6] Statin therapy tends to not show any histopathological differences, and thus a biopsy does not reveal too much about the damage. Often, the damage is found within the mitochondria.
New research published in The Lancet says statins, the cholesterol-managing drug, do not cause muscle pain, despite them being commonly linked.
While it’s important to treat heart disease risks before a first event, statins can cause side effects for some, including muscle pain, headaches, sleep problems and digestive problems.
The known cardiovascular benefits of atorvastatin over time outweigh the low risk of muscle-related side effects. [63] [62] Statin-induced rhabdomyolysis is rare, occurring in less than 0.1% of people who take statins. [64] [65] [66] Statin induced rhabdomyolysis, as with other statin associated muscle symptoms, occurs most commonly in the ...
Why statins are prescribed Women develop cardiovascular disease less often than men, according to a study published in 2023. However, they have a higher rate of death from cardiovascular disease.
A 2010 published meta-analysis found for every 255 patients taking a statin for 4 years, one additional case of diabetes would occur whilst preventing 5.4 major coronary events. [27] Some drugs interact with statins in a way that increases the risk of muscle injury called myopathy, characterized by unexplained muscle weakness or pain.