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  2. Dobutamine - Wikipedia

    en.wikipedia.org/wiki/Dobutamine

    Dobutamine is a medication used in the treatment of cardiogenic shock (as a result of inadequate tissue perfusion) and severe heart failure. [ 2 ] [ 3 ] It may also be used in certain types of cardiac stress tests . [ 2 ]

  3. Cardiotonic agent - Wikipedia

    en.wikipedia.org/wiki/Cardiotonic_agent

    Cardiotonic agents, also known as cardiac inotropes or stimulants, have a positive impact on the myocardium (muscular layer of the heart) by enhancing its contractility. . Unlike general inotropes, these agents exhibit a higher level of specificity as they selectively target the myocar

  4. Dose–response relationship - Wikipedia

    en.wikipedia.org/wiki/Dose–response_relationship

    Dose response curves are typically fitted to the Hill equation. The first point along the graph where a response above zero (or above the control response) is reached is usually referred to as a threshold dose. For most beneficial or recreational drugs, the desired effects are found at doses slightly greater than the threshold dose.

  5. Omecamtiv mecarbil - Wikipedia

    en.wikipedia.org/wiki/Omecamtiv_mecarbil

    Clinical studies on humans have shown there is a direct linear relationship between dose and systolic ejection time. [2] [13] [14] The dose-dependent effects persisted throughout the entire trial, suggesting that desensitization does not occur. The maximum tolerated dose was observed to be an infusion of 0.5 mg/kg/h.

  6. Sympathomimetic drug - Wikipedia

    en.wikipedia.org/wiki/Sympathomimetic_drug

    Examples of sympathomimetic effects include increases in heart rate, force of cardiac contraction, and blood pressure. [1] The primary endogenous agonists of the sympathetic nervous system are the catecholamines (i.e., epinephrine [adrenaline], norepinephrine [noradrenaline], and dopamine ), which function as both neurotransmitters and hormones .

  7. Tachyphylaxis - Wikipedia

    en.wikipedia.org/wiki/Tachyphylaxis

    Tachyphylaxis (Greek ταχύς, tachys, "rapid", and φύλαξις, phylaxis, "protection") is a medical term describing an acute, sudden decrease in response to a drug after its administration (i.e., a rapid and short-term onset of drug tolerance). [1]

  8. Threshold dose - Wikipedia

    en.wikipedia.org/wiki/Threshold_dose

    Threshold dose is the minimum dose of drug that triggers minimal detectable biological effect in an animal. [1] At extremely low doses, biological responses are absent for some of the drugs. The increase in dose above threshold dose induces an increase in the percentage of biological responses. [ 2 ]

  9. Mephentermine - Wikipedia

    en.wikipedia.org/wiki/Mephentermine

    For maintenance of blood pressure in hypotensive states, the dose for adults is 30 to 45 mg as a single dose, repeated as necessary or followed by intravenous infusion of 0.1% mephentermine in 5% dextrose, with the rate and duration of administration depending on the patient's response.