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Ceftriaxone, sold under the brand name Rocephin, is a third-generation cephalosporin antibiotic used for the treatment of a number of bacterial infections. [4] These include middle ear infections, endocarditis, meningitis, pneumonia, bone and joint infections, intra-abdominal infections, skin infections, urinary tract infections, gonorrhea, and pelvic inflammatory disease. [4]
For gonorrhea typically only one dose is required. [6] In the United States it is a second-line treatment to ceftriaxone for gonorrhea. [5] It is taken by mouth. [5] Common side effects include diarrhea, abdominal pain, and nausea. [5] Serious side effects may include allergic reactions and Clostridioides difficile diarrhea. [5]
Over-the-counter (OTC) medications are generally first-line therapies that people may choose to treat common acute illnesses, such as fevers, colds, allergies, headaches, or other pain. Many of these medications can be bought in retail pharmacies or grocery stores without a prescription.
Pfizer acknowledged reducing the dose of the standard treatment, but said this was done to minimize injection-site pain and that the mortality rates in both the trovafloxin and ceftriaxone arms of its trial were lower than among those treated with chloramphenicol by Médecins Sans Frontières. [7]
Since August 2012, the third-generation cephalosporin, ceftriaxone, is the only recommended treatment for gonorrhea in the United States (in addition to azithromycin or doxycycline for concurrent Chlamydia treatment). Cefixime is no longer recommended as a first-line treatment due to evidence of decreasing susceptibility. [30] Ceftriaxone ...
Disadvantages include the possibility that a patient will use the pain medication non-medically, self-administering the narcotic for its euphoric properties even though the patient's pain is sufficiently controlled. If a PCA device is not programmed properly for the patient this can result in an under-dose or overdose in a medicine. [22]
Treatment of Clostridioides (formerly Clostridium) difficile infection. [8] May be more narrow-spectrum than vancomycin, resulting in less bowel microbiota alteration. [9] Nausea (11%), vomiting, and abdominal pain. [10] Bactericidal in susceptible organisms such as C. difficile by inhibiting RNA polymerase, thereby inhibiting protein synthesis ...
Initial treatment typically includes antibiotics such as vancomycin, ceftriaxone or ceftazidime. [2] Surgery in the form of joint drainage is the gold standard management in large joints like the hip and shoulder. [2] [5] [8] Without early treatment, long-term joint problems may occur, such as irreversible joint destruction and dislocation. [2]
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