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Eurycomanone is a chemical compound that has been isolated from Eurycoma longifolia, also known as the longjack plant or tongkat ali. [1] Eurycomanone is distributed throughout the plant, with the highest concentration in leaves. Researchers measured 6.0568 μg/mL in leaves, and only 0.3533 μg/mL in roots. [2]
Eurycoma longifolia (commonly called tongkat ali, Malaysian ginseng or long jack) [3] is a flowering plant in the family Simaroubaceae. It is native to Indochina (Cambodia, Laos, Malaysia, Myanmar, Thailand and Vietnam) and Indonesia (the islands of Borneo and Sumatra ), [ 4 ] but has also been found in the Philippines. [ 5 ]
Damage to DNA that occurs naturally can result from metabolic or hydrolytic processes. Metabolism releases compounds that damage DNA including reactive oxygen species, reactive nitrogen species, reactive carbonyl species, lipid peroxidation products, and alkylating agents, among others, while hydrolysis cleaves chemical bonds in DNA. [8]
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Tongkat Ali (a.k.a. Long Jack) is marketed by several off-shore sources, trumpeted as a testosterone booster, without the side-effects of direct testosterone supplementation. In what appear to be limited trials, results reported include 200% to 400% increase in testosterone and free testerone levels. This seems remarkable.
Nucleotide excision repair (NER) is a particularly important excision mechanism that removes DNA damage induced by ultraviolet light (UV). UV DNA damage results in bulky DNA adducts — these adducts are mostly thymine dimers and 6,4-photoproducts. Recognition of the damage leads to removal of a short single-stranded DNA segment that contains ...
In fact, according to a 2022 research review, there is some limited evidence that Vicks can help improve toenail fungus. One of the studies included in the review found that of 18 people, 15 saw ...
Most of the DNA repair deficiency diseases show varying degrees of "accelerated aging" or cancer (often some of both). [37] But elimination of any gene essential for base excision repair kills the embryo—it is too lethal to display symptoms (much less symptoms of cancer or "accelerated aging"). [38]
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