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A general purpose DEVS methodology based software environment for discrete event and hybrid models. July 23, 2015 [9] Plant Simulation: Siemens PLM Software: Software that enables the simulation and optimization of production systems and processes. May 3, 2019 [10] Simcad Pro: CreateASoft, Inc Discrete event simulation software.
Prolinol is obtained by reduction of the amino acid proline using lithium aluminium hydride. [ 2 ] [ 3 ] Because proline is cheaply available in high optical purity, enantiomerically pure prolinol is also widely available.
Proline acts as a structural disruptor in the middle of regular secondary structure elements such as alpha helices and beta sheets; however, proline is commonly found as the first residue of an alpha helix and also in the edge strands of beta sheets.
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Proline organocatalysis is the use of proline as an organocatalyst in organic chemistry. This theme is often considered the starting point for the area of organocatalysis, even though early discoveries went unappreciated. [ 1 ]
The biochemical mechanism of proline racemase was first put forward in the late sixties by Cardinale and Abeles [6] using the Clostridium sticklandii enzyme, CsPRAC. The catalytic mechanism of proline racemase was late revisited by Buschiazzo, Goytia and collaborators that, in 2006, resolved the structure of the parasite TcPRAC co-crystallyzed with its known competitive inhibitor - pyrrole ...
Arginine and proline metabolism is one of the central pathways for the biosynthesis of the amino acids arginine and proline from glutamate. The pathways linking arginine, glutamate, and proline are bidirectional. Thus, the net utilization or production of these amino acids is highly dependent on cell type and developmental stage.
The Hajos–Parrish–Eder–Sauer–Wiechert and Barbas-List [1] reactions in organic chemistry are a family of proline-catalysed asymmetric aldol reactions.. In the 1970s, two research groups discovered (and published) almost simultaneously their discoveries of two related intramolecular reactions: Zoltan Hajos and David Parrish at Hoffmann-La Roche [2] [3] and Rudolf Wiechert et al at ...