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Polyvinylpyrrolidone (PVP), also commonly called polyvidone or povidone, is a water-soluble polymer compound made from the monomer N-vinylpyrrolidone. [1] PVP is available in a range of molecular weights and related viscosities, and can be selected according to the desired application properties.
Polyvinylpolypyrrolidone (polyvinyl polypyrrolidone, PVPP, crospovidone, crospolividone, or E1202) is a highly cross-linked modification of polyvinylpyrrolidone (PVP).. The cross-linked form of PVP is used as a disintegrant (see also excipients) in pharmaceutical tablets. [1]
Innocenti et al. [2] studied Gelclair in a total of thirty patients with chemotherapy-induced oral lesions. Results showed a 92% reduction in mean pain scores 5–7 hours after the first administration of Gelclair. Patients were also given Gelclair for a further 7–10 days and at the end of this period, pain scores were recorded.
It is produced industrially by vinylation of 2-pyrrolidone, i.e. the base-catalyzed reaction with acetylene. [2] It is the precursor to polyvinylpyrrolidone (PVP), an important synthetic material. The NVP monomer is commonly used as a reactive diluent in ultraviolet and electron-beam curable polymers applied as inks, coatings or adhesives. [2]
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Povidone-iodine is a chemical complex of the polymer povidone (polyvinylpyrrolidone, PVP) and triiodide (I − 3). [24] It is synthesized by mixing the PVP polymer with iodine (I 2), allowing the two to react. [25] It is soluble in cold and mild-warm water, ethyl alcohol, isopropyl alcohol, polyethylene glycol, and glycerol.
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