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Lipoic acid (LA), also known as α-lipoic acid, alpha-lipoic acid (ALA) and thioctic acid, is an organosulfur compound derived from caprylic acid (octanoic acid). [3] ALA, which is made in animals normally, is essential for aerobic metabolism. It is also available as a dietary supplement or pharmaceutical drug in some countries.
Calcium gluconate is the calcium salt of gluconic acid and is used as a mineral supplement and medication. [1] As a medication it is used by injection into a vein to treat low blood calcium, high blood potassium, and magnesium toxicity. [1] [2] Supplementation is generally only required when there is not enough calcium in the diet. [3]
Poly-MVA (or Lipoic Acid Mineral Complex) is a dietary supplement created by Merrill Garnett (1931–), a former dentist turned biochemist. Poly-MVA is an unproven alternative cancer treatment. [ 1 ]
Blood pressure varies over longer time periods (months to years) and this variability predicts adverse outcomes. [18] Blood pressure also changes in response to temperature, noise, emotional stress, consumption of food or liquid, dietary factors, physical activity, changes in posture (such as standing-up), drugs, and disease. [19]
A 2016 meta-analysis concluded that grape seed extract, in a dose of under 800 milligrams per day over at least 8 weeks, might help to reduce systolic and diastolic blood pressure. [7] People with metabolic syndrome had a more significant outcome (average of a 8½ mmHg decrease in systolic blood pressure) than in healthy subjects. [7]
l-DOPA is produced from the amino acid l-tyrosine by the enzyme tyrosine hydroxylase. l-DOPA can act as an l-tyrosine mimetic and be incorporated into proteins by mammalian cells in place of l-tyrosine, generating protease-resistant and aggregate-prone proteins in vitro and may contribute to neurotoxicity with chronic l-DOPA administration. [10]
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