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The 3 core sciences namely Biology, Chemistry, and Physics will be updated for first teaching in August 2023, with first examinations in May 2025. The syllabus change was originally scheduled for 2021, though the COVID-19 pandemic caused the IB to delay the syllabus change to 2023. Details of the specific changes can be found on the IBO website.
Type IB topoisomerases change the linking number by multiples of 1 (n). Historically, type IA topoisomerases are referred to as prokaryotic topo I, while type IB topoisomerases are referred to as eukaryotic topoisomerase. This distinction, however, no longer applies as type IA and type IB topoisomerases exist in all domains of life ...
Examples of type IA topoisomerases include prokaryotic topo I and III, eukaryotic topo IIIα and IIIβ and the archaeal enzyme reverse gyrase. Reverse gyrase, which occurs in thermophilic archaea, comprises a type IA topo coupled to a helicase, and is the only known enzyme that can introduce positive supercoils into DNA. [ 24 ]
Class IA PI 3-kinases are activated by receptor tyrosine kinases (RTKs). There are three catalytic subunits that are classified as class IA PI 3-kinases: [citation needed] p110α; p110β; p110δ; There are currently five regulatory subunits that are known to associate with class IA PI 3-kinases catalytic subunits: [citation needed] p85α and ...
Also biobanks, which do specimen storage, cannot take full responsibility for specimen integrity, because before they take custody of samples someone must collect and process them and effects such as RNA degradation are more likely to occur from delayed sample processing than inadequate storage.
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Topoisomerase inhibitor classes have been derived from a wide variety of disparate sources, with some being natural products first extracted from plants (camptothecin, [10] etoposide [13]) or bacterial samples (doxorubicin, [14] indolocarbazole [15]), while others possess purely synthetic, and often accidental, origins (quinolone, [11 ...