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The rare genetic disorders familial juvenile hyperuricemic nephropathy, medullary cystic kidney disease, phosphoribosylpyrophosphate synthetase superactivity and hypoxanthine-guanine phosphoribosyltransferase deficiency as seen in Lesch–Nyhan syndrome, are complicated by gout.
Since the HPRT gene is located on the X chromosome, LNS is an X-linked inherited disease. [citation needed] The father of an affected male will not be the carrier of the mutant allele, and will not have the disease. An obligate carrier would be a woman who has an affected son and one other affected relative in the maternal line. [citation needed]
The following is a list of genetic disorders and if known, type of mutation and for the chromosome involved. Although the parlance "disease-causing gene" is common, it is the occurrence of an abnormality in the parents that causes the impairment to develop within the child. There are over 6,000 known genetic disorders in humans.
Periods when gout symptoms are more severe are called gout flares or gout attacks. ... Heart disease like heart failure and coronary ... Family history of gout. Genetics can contribute to high ...
Unless high blood levels of uric acid are determined in a clinical laboratory, hyperuricemia may not cause noticeable symptoms in most people. [4] Development of gout – which is a painful, short-term disorder – is the most common consequence of hyperuricemia, which causes deposition of uric acid crystals usually in joints of the extremities, but may also induce formation of kidney stones ...
This occurs from a combination of diet, other health problems, and genetic factors. [3] [2] At high levels, uric acid crystallizes and the crystals deposit in joints, tendons, and surrounding tissues, resulting in an attack of gout. [3]
A 2011 survey in the United States indicated that 3.9% of the population had gout, whereas 21.4% had hyperuricemia without having symptoms. [ 43 ] Excess blood uric acid (serum urate) can induce gout , [ 44 ] a painful condition resulting from needle-like crystals of uric acid termed monosodium urate crystals [ 45 ] precipitating in joints ...
Genetics. A family history of osteoarthritis can predispose you to develop the disease earlier or experience it more severely. Over 100 gene variations have been associated with the development of ...