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The Parietal Cell: Mechanism of Acid Secretion at vivo.colostate.edu; Histology image: 11303loa – Histology Learning System at Boston University - Digestive System: Alimentary Canal: fundic stomach, gastric glands, lumen" Nosek, Thomas M. "Section 6/6ch4/s6ch4_8". Essentials of Human Physiology. Archived from the original on 2016-03-24.
These cells almost fill the tube and the remaining lumen is continued as a very fine channel. Cells found in the gastric glands include mucous neck cells, chief cells, parietal cells, G cells, and enterochromaffin-like cells (ECLs). The first cells of all of the glands are mucus-secreting foveolar cells that line the gastric pits.
The parietal cells in the fundus of the stomach, produce a glycoprotein called intrinsic factor which is essential for the absorption of vitamin B12. Vitamin B12 (cobalamin), is carried to, and through the stomach, bound to a glycoprotein secreted by the salivary glands – transcobalamin I also called haptocorrin, which protects the acid ...
About 20,000 protein-coding genes are expressed in human cells and nearly 70% of these genes are expressed in the normal stomach. [ 27 ] [ 28 ] Just over 150 of these genes are more specifically expressed in the stomach compared to other organs, with only some 20 genes being highly specific.
The mucus produced by these cells is extremely important, as it prevents the stomach from digesting itself. [5] Parietal cells produce potent hydrochloric acid, which damages cells. Gastric chief cells produce pepsinogen, which is activated by the acid to form pepsin. Pepsin is a protease that can digest and damage stomach cells.
Mucus is released in the stomach and intestine, and serves to lubricate and protect the inner mucosa of the tract. It is composed of a specific family of glycoproteins termed mucins and is generally very viscous. Mucus is made by two types of specialized cells termed mucous cells in the stomach and goblet cells in the intestines. Signals for ...
Several types of endocrine cells are found in the gastric glands. The pyloric glands contain gastrin -producing cells ( G cells ); this hormone stimulates acid production from the parietal cells. Enterochromaffin-like cells (ECLs), found in the oxyntic glands release histamine , which also is a powerful stimulant of the acid secretion.
The stomach has an extra layer, an inner oblique muscular layer. [1] Between the two muscle layers is the myenteric plexus (Auerbach's plexus). This controls peristalsis. Activity is initiated by the pacemaker cells (interstitial cells of Cajal).