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The ability to retain moisture depends on the lipid bilayer between the dead skin cells. [4] Moisturizers modify the rate of water loss, with active ingredients of moisturizers falling into one of two categories: occlusives and humectants. [5] Occlusives form a hydrophobic coating on the surface of the skin, keeping moisture from escaping. The ...
[1] [6] This occlusive layer traps moisture, allowing hydration of the skin and providing an emollient effect. [1] [6] [10] This emollient effect is particularly helpful in formulation of topical gels for patients with dry and irritated skin. [1] Hydrogel used for wound dressing
Hyaluronic acid is also a major component of skin, where it is involved in repairing tissue. When skin is exposed to excessive UVB rays, it becomes inflamed , and the cells in the dermis stop producing as much hyaluronan and increase the rate of its degradation. Hyaluronan degradation products then accumulate in the skin after UV exposure.
Maceration is defined as the softening and breaking down of skin resulting from prolonged exposure to moisture. It was first described by Jean-Martin Charcot in 1877. [1] [2] Maceration is caused by excessive amounts of fluid remaining in contact with the skin or the surface of a wound for extended periods.
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