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Avascular necrosis (AVN), also called osteonecrosis or bone infarction, is death of bone tissue due to interruption of the blood supply. [1] Early on, there may be no symptoms. [1] Gradually joint pain may develop, which may limit the person's ability to move. [1] Complications may include collapse of the bone or nearby joint surface. [1]
The major tissues affected are nerves and muscles, where irreversible damage starts to occur after 4–6 hours of cessation of blood supply. [4] Skeletal muscle, the major tissue affected, is still relatively resistant to infarction compared to the heart and brain because its ability to rely on anaerobic metabolism by glycogen stored in the cells may supply the muscle tissue long enough for ...
A sequestrum (plural: sequestra) is a piece of dead bone [1] that has become separated during the process of necrosis from normal or sound bone. It is a complication (sequela) of osteomyelitis. The pathological process is as follows: infection in the bone leads to an increase in intramedullary pressure due to inflammatory exudates
Necrotic bone and inflammation histology slide. The current etiology or origin of this disease is unknown. Some studies theorized that bone remodeling is maintained in a microenvironment in the FH meaning that there is a greater local component to changes to the femoral head than the normal systemic way that bone remodeling is handled throughout the body.
The long bones of the human leg comprise nearly half of adult height. The other primary skeletal component of height are the vertebrae and skull. The outside of the bone consists of a layer of connective tissue called the periosteum. Additionally, the outer shell of the long bone is compact bone, then a deeper layer of cancellous bone (spongy ...
The femur is the largest and thickest bone in the human body. It is considered the strongest bone by some measures, though other studies suggest the temporal bone may be stronger. On average, the femur length accounts for 26.74% of a person's height, [4] a ratio found in both men and women across most ethnic groups with minimal
These bones are located just beyond the wrist and serve as a link to the phalanges, or finger bones, at the end of the limbs. In the lower body, the femur is a prominent bone positioned between the hip and knee. As the longest bone in the human body, it plays a pivotal role in forming the upper part of the knee joint.
The epiphyseal plate, epiphysial plate, physis, or growth plate is a hyaline cartilage plate in the metaphysis at each end of a long bone.It is the part of a long bone where new bone growth takes place; that is, the whole bone is alive, with maintenance remodeling throughout its existing bone tissue, but the growth plate is the place where the long bone grows longer (adds length).