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The test was first developed by Dr. Carol Barnes in 1979. [1] The test subjects are usually rodents such as mice or lab rats , which either serve as a control or may have some genetic variable or deficiency present in them which will cause them to react to the maze differently.
The hole-board test (HBT) is an experimental method used in scientific research to measure anxiety, stress, neophilia and emotionality in animals. [ 1 ] [ 2 ] [ 3 ] Because of its ability to measure multiple behaviors it is a popular test in behavioral pharmacology , but the results are controversial.
Different labs account variable results due to the differences between the type and severity of external stressors. Baseline levels in the control group which are key in determining the exploratory activity can vary due to strain, age, and weight. [4] The LDB has not been validated for female rodents. [4] The LDB can give too many false positives.
When the test was first developed, it was pharmacologically validated through the use of benzodiazepines, a common anxiety medication. Newer drugs such as 5-HT-1A partial agonists and selective serotonin reuptake inhibitors , which have also been proven to treat anxiety, show inconsistent results in this test.
The test was developed to study spatial learning and how it differed from other forms of associative learning. [11] Originally rats, now more commonly mice, were placed in an open pool and the latency to escape was measured for up to six trials a day for 2–14 days. [ 12 ]
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