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The first left ventricular assist device (LVAD) system was created by Domingo Liotta at Baylor College of Medicine in Houston in 1962. The first LVAD was implanted in 1963 by Liotta and E. Stanley Crawford. The first successful implantation of an LVAD was completed in 1966 by Liotta along with Dr. Michael E. DeBakey.
One parameter to quantify this difference is the pulsatility index (PI), which is equal to the difference between the peak systolic velocity and the minimum diastolic velocity divided by the mean velocity during the cardiac cycle. This value decreases with distance from the heart.
Thoratec's third-generation HeartMate LVAD is the HeartMate 3, [48] [49] designed to lower adverse event rates through improved hemocompatibility, and to increase ease of surgical placement through new design and compact size. [50] [51] It began undergoing clinical trials in the U.S. and internationally in mid 2014. [48] [49] [50] [52] [53]
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During the REMATCH trial, several complications were reported for patients who received the LVAD. They reported post-operative pain after LVAD implantation. During an average 400 days of survival, 30 percent of the devices had an internal failure requiring another operation, and almost every patient who had a re-operation did not survive.