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To induce general anesthesia, propofol is the drug used almost exclusively, having largely replaced sodium thiopental. [13]It is often administered as part of an anesthesia maintenance technique called total intravenous anesthesia, using either manually programmed infusion pumps or computer-controlled infusion pumps in a process called target controlled infusion (TCI).
Phar-Mor (stylized as PHA℞-MOR) was a United States chain of discount drug stores, based in Youngstown, Ohio, and founded by Michael "Mickey" Monus and David Shapira in 1982. Some of its stores used the names Pharmhouse and Rx Place (purchased in the mid-1990s from the F.W. Woolworth Company). Low prices were advertised to bring in a large ...
Propofol infusion syndrome (PRIS) is a rare syndrome which affects patients undergoing long-term treatment with high doses of the anaesthetic and sedative drug propofol. It can lead to cardiac failure , rhabdomyolysis , metabolic acidosis , and kidney failure , and is often fatal.
In 1983, a lipid emulsion formulation of propofol was available, which carried great potential during clinical trials. [8] It was licensed for use in Europe in 1986 and received FDA approval in the US in 1989. [1] Propofol is now used worldwide with a well-defined pharmacological profile for a variety of medical uses.
Ciprofol (also known as cipepofol, or HSK3486) is a novel 2,6-disubstituted phenol derivative that is used for the intravenous induction of general anesthesia. [1] [2] A short-acting and highly selective γ-aminobutyric acid agonist, [3] ciprofol is 4–6 times more potent than other phenol derivatives such as propofol or fospropofol.
It had been several years since professor Joseph Palamar had seen that unmistakable “caveman face,” the telltale sign of an imminent overdose of gamma-hydroxybutyric acid, or GHB. “I’ve ...
Other intravenous anesthetic drugs such as midazolam or propofol may be used. [1] [2] Drug-induced comas are used to protect the brain during major neurosurgery, as a last line of treatment in certain cases of status epilepticus that have not responded to other treatments, [2] and in refractory intracranial hypertension following traumatic ...
Other national drug prohibition laws include the Controlled Drugs and Substances Act and the Misuse of Drugs Act 1975 (New Zealand), among many others. Within Europe controlled substance laws are legislated at the national rather than by the EU itself, with significant variation between countries in which and how chemicals are classified as ...