Search results
Results from the WOW.Com Content Network
Positive inotropes are used to support cardiac function in conditions such as decompensated congestive heart failure, cardiogenic shock, septic shock, myocardial infarction, cardiomyopathy, etc. [10] Examples of positive inotropic agents include: [citation needed] Digoxin; Berberine; Calcium; Calcium sensitisers Levosimendan [11] Catecholamines ...
Their inotropic properties make cardiactonic agents critical in addressing inadequate perfusion, and acute heart failure conditions including cardiogenic shock, as well as for long-term management of heart failure. These conditions arise when the heart's ability to meet the body's needs is compromised.
They are a class of sympathomimetic agents, each acting upon the beta adrenoceptors. [2] In general, pure beta-adrenergic agonists have the opposite function of beta blockers : beta-adrenoreceptor agonist ligands mimic the actions of both epinephrine - and norepinephrine - signaling, in the heart and lungs, and in smooth muscle tissue ...
Haemorrhagic shock: Hypovolemia (Hypovolemic shock) Intravascular volume status Heart rate (Tachycardia) / Systolic blood pressure (Hypotension) / Decreased urine output: Intravenous fluid / Intraosseous infusion / Blood transfusion with packed red blood cells: Cardiogenic shock: Cardiac output: Positive inotropic agents / Chronotropes ...
Mephentermine appears to act by indirect stimulation of β-adrenergic receptors through causing the release of norepinephrine from its storage sites. It has a positive inotropic effect on the myocardium. AV conduction and refractory period of AV node is shortened with an increase in ventricular conduction velocity. It dilates arteries and ...
A "heterocycle-phenyl-imidazole" (H-P-I) pattern has been considered to be necessary for positive inotropic activity in cardiac muscle and many second generation inhibitors fit this pattern. [ 6 ] The heterocycle region : Within each heterocycle there is the presence of a dipole and an adjacent acid proton (an amide function).
A cardiac stimulant is a drug which acts as a stimulant of the heart – e.g., via positive chronotropic action (increased heart rate) and/or inotropic action (increased myocardial contractility). They increase cardiac output (the amount of blood pumped by the heart over time).
Drugs that positively render the effects of catecholamines such as norepinephrine and epinephrine that enhance contractility are considered to have a positive inotropic effect. The ancient herbal remedy digitalis appears to have both inotropic and chronotropic properties that have been recorded encyclopedically for centuries and it remains ...