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The reaction generally includes a constellation of fever; urticarial polycyclic wheals (a rash that can look similar to hives with small swellings that overlap each other [2]) with central clearing on the trunk, extremities, face, and lateral borders of the hands and feet; oral edema without mucosal involvement; lymphadenopathy; arthralgias; myalgias; and mild proteinuria.
This is a list of drugs and substances that are known or suspected to cause Stevens–Johnson syndrome This is a dynamic list and may never be able to satisfy particular standards for completeness. You can help by adding missing items with reliable sources .
Spironolactone can cause hyperkalemia, or high blood potassium levels. [111] Rarely, this can be fatal. [111] Of people with heart disease prescribed typical dosages of spironolactone, 10 to 15% develop some degree of hyperkalemia, and 6% develop severe hyperkalemia. [111] At a higher dosage, a rate of hyperkalemia of 24% has been observed. [119]
The condition causes inflamed patches of skin that can look like a rash, Elbuluk says. Those areas of skin may feel dry, scaly or itchy, and can flake off. Other symptoms:
A skin biopsy, blood tests or immunological tests can also be useful. Drug reactions have characteristic timing. The typical amount of time it takes for a rash to appear after exposure to a drug can help categorize the type of reaction. For example, Acute generalized exanthematous pustulosis usually occurs within 4 days of starting the culprit ...
The bacteria releases a toxin that causes a bright red blotchy rash that has a sandpaper-like texture, and the rash can spread to the entire body and usually first appears on the groin, neck, and ...
They can be found circulating in the blood, which differentiates serum sickness from serum sickness-like reaction. [4] The result is a leukocytoclastic vasculitis. [2] This results in hypocomplementemia, a low C3 level in serum. [2] They can also cause more reactions, causing the typical symptoms of serum sickness.
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