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Lidocaine is an antiarrhythmic medication of the class Ib type. [7] This means it works by blocking sodium channels thus decreasing the rate of contractions of the heart. [10] [7] When injected near nerves, the nerves cannot conduct signals to or from the brain. [8] Lidocaine was discovered in 1946 and went on sale in 1948. [11]
The GI cocktail is a mixture of a viscous anesthetic, an antacid, and an anticholinergic. [1] [2] Common viscous anesthetics use are viscous lidocaine or xylocaine.Common antacids used are magnesium hydroxide, aluminum hydroxide, or simethicone (more commonly known as Mylanta or Maalox). [3]
The most common combination of agents used in tumescent anesthesia is lidocaine (0.05-0.10%) and epinephrine (1 ppm). [3] [4] [5] For lidocaine, total doses of 35 mg/kg [6] and 55 mg/kg [7] have been reported as reasonably safe high-end doses, in the context of liposuction.
The pink lady is the de facto term describing xylocaine viscous and a liquid antacid given by mouth to treat emergency department patients and help determine if the chest pains are either heart or digestive related. If esophageal symptoms subside the treatment may indicate the symptoms are non-cardiac.
It is a colorless viscous liquid. Commercially significant derivatives are the anesthetics lidocaine, bupivacaine, mepivacaine, and etidocaine. [1]
Functionally, the device is gently inserted through a patient's nose after careful lubrication with a viscous lidocaine gel. Successful placement will facilitate spontaneous ventilation, masked ventilation, or machine assisted ventilation with a modified nasopharyngeal airway designed with special attachments at the proximal end.
However, care should be taken as the high doses of viscous lidocaine my cause adverse effects. [12] A study reported that lidocaine has a potential toxicity; when it was tested on patients with oral mucositis who underwent a bone marrow transplant, lidocaine anesthetic mouthwash was found to be systemically absorbed. [13]
Lidocaine/prilocaine is a eutectic mixture of equal quantities (by weight) of lidocaine and prilocaine. A 5% emulsion preparation, containing 2.5% each of lidocaine/prilocaine, is marketed by APP Pharmaceuticals under the trade name EMLA (an abbreviation for Eutectic Mixture of Local Anesthetics ). [ 5 ]
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