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Effects of long-term benzodiazepine use may include disinhibition, impaired concentration and memory, depression, [19] [20] as well as sexual dysfunction. [6] [21] The long-term effects of benzodiazepines may differ from the adverse effects seen after acute administration of benzodiazepines. [22]
The long-term effects of benzodiazepines are still not fully understood. Long-term benzodiazepine use is associated with attentional and visuospatial functional impairments. Withdrawal from benzodiazepines can lead to improved alertness and decreased forgetfulness in the elderly. Withdrawal led to statistically significant improvements in ...
Benzodiazepine use disorder (BUD), also called misuse or abuse, [1] is the use of benzodiazepines without a prescription and/or for recreational purposes, which poses risks of dependence, withdrawal and other long-term effects. [2] [3] Benzodiazepines are one of the more common
Some doctors feel that the long-term risks are so great that it’s best not to use them at all. ... Benzodiazepine Side Effects. Benzodiazepines can cause side effects, including some that may ...
Benzodiazepines potentiate the action of GABA, [54] by binding a site between the α and γ subunits of the 5-subunit receptor [55] thereby increasing the frequency of the GABA-gated chloride channel opening in the presence of GABA. [56] When potentiation is sustained by long-term use, neuroadaptations occur which result in decreased GABAergic ...
A number of studies have drawn an association between long-term benzodiazepine use and neuro-degenerative disease, particularly Alzheimer's disease. [150] It has been determined that long-term use of benzodiazepines is associated with increased dementia risk, even after controlling for protopathic bias. [13]
The involvement of glutamate in benzodiazepine dependence explains long-term potentiation as well as neuro-kindling phenomena. There is some evidence that a prior history of CNS depressant dependence (e.g. alcohol) increases the risk of dependence on benzodiazepines.
Of the 74, 53 had some experience with 12-step or abstinence-based treatment. Their involvement in such programs ran the gamut from multiple long-term residential and detox stays to outpatient treatment and court-ordered attendance at Narcotics Anonymous meetings. These were addicts who wanted to stop using, or at least heard the message.