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Cimetidine is rapidly absorbed regardless of route of administration. [7] The oral bioavailability of cimetidine is 60 to 70%. [5] [6] The onset of action of cimetidine when taken orally is 30 minutes, [8] and peak levels occur within 1 to 3 hours. [5] Cimetidine is widely distributed throughout all tissues. [7]
Cimetidine was the first drug ever to reach more than $1 billion a year in sales, thus making it the first blockbuster drug. [ 26 ] In the pharmaceutical industry, a blockbuster drug is one that achieves acceptance by prescribing physicians as a therapeutic standard for, most commonly, a highly prevalent chronic (rather than acute) condition.
Cimetidine was the prototypical histamine H 2 receptor antagonist from which later drugs were developed. Cimetidine was the culmination of a project at Smith, Kline & French (SK&F; now GlaxoSmithKline) by James W. Black, C. Robin Ganellin, and others to develop a histamine receptor antagonist that would suppress stomach acid secretion.
What could be behind not pooping as often? Experts say diet is the most common cause. (Photo illustration: Yahoo News; photo: Getty Images) (Photo illustration: Yahoo News; photo: Getty Images)
Notable drugs that experience a significant first pass effect are buprenorphine, chlorpromazine, cimetidine, diazepam, ethanol (drinking alcohol), imipramine, insulin, lidocaine, midazolam, morphine, pethidine, propranolol, and tetrahydrocannabinol (THC). First-pass metabolism is not to be confused with Phase I metabolism, which is a separate ...
What I liked about Storyworth. There’s a lot to like about Storyworth, assuming you either choose to answer the questions yourself or choose to pepper a willing participant.
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