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Cimetidine is rapidly absorbed regardless of route of administration. [7] The oral bioavailability of cimetidine is 60 to 70%. [5] [6] The onset of action of cimetidine when taken orally is 30 minutes, [8] and peak levels occur within 1 to 3 hours. [5] Cimetidine is widely distributed throughout all tissues. [7]
Cimetidine was the prototypical histamine H 2 receptor antagonist from which later drugs were developed. Cimetidine was the culmination of a project at Smith, Kline & French (SK&F; now GlaxoSmithKline) by James W. Black, C. Robin Ganellin, and others to develop a histamine receptor antagonist that would suppress stomach acid secretion.
Cimetidine was the first drug ever to reach more than $1 billion a year in sales, thus making it the first blockbuster drug. [ 26 ] In the pharmaceutical industry, a blockbuster drug is one that achieves acceptance by prescribing physicians as a therapeutic standard for, most commonly, a highly prevalent chronic (rather than acute) condition.
Cases of norovirus are spiking in the U.S. along with other illnesses in what some are calling a “quad-demic” of viruses. Often referred to as the stomach flu, noroviruses aren’t actually ...
What could be behind not pooping as often? Experts say diet is the most common cause. (Photo illustration: Yahoo News; photo: Getty Images) (Photo illustration: Yahoo News; photo: Getty Images)
The Autoimmune Protocol (AIP) diet is an elimination diet designed to help reduce inflammation, manage symptoms and improve quality of life for people with autoimmune diseases.
Notable drugs that experience a significant first pass effect are buprenorphine, chlorpromazine, cimetidine, diazepam, ethanol (drinking alcohol), imipramine, insulin, lidocaine, midazolam, morphine, pethidine, propranolol, and tetrahydrocannabinol (THC). First-pass metabolism is not to be confused with Phase I metabolism, which is a separate ...
Cimetidine 1983 January: Two letters authored by Warren and Marshall, respectively, are sent to The Lancet describing their results. [38] February: Gastroenterological Society of Australia rejects Marshall's abstract to present his research at their yearly conference. They deem it in the bottom 10% of papers submitted.