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A Howell–Jolly body (marked by arrow) within an erythrocyte. A Howell–Jolly body is a cytopathological finding of basophilic nuclear remnants (clusters of DNA) in circulating erythrocytes. During maturation in the bone marrow, late erythroblasts normally expel their nuclei; but, in some cases, a small portion of DNA remains. The presence of ...
Splenectomy patients typically have Howell-Jolly bodies [11] [12] and less commonly Heinz bodies in their blood smears. [13] Heinz bodies are usually found in cases of G6PD (Glucose-6-Phosphate Dehydrogenase) and chronic liver disease. [14] A splenectomy also results in a greatly diminished frequency of memory B cells. [15]
Howell–Jolly bodies are found on red blood cells and contain chromatin remnants from basophilic cells. [7] Under normal conditions, these nuclear remnants are removed from the blood by the spleen's filtering capabilities. Howell-Jolly bodies can be identified and quantified using a blood smear or by flow cytometry. [2]
Howell-Jolly body-like inclusions (HJBLi) are a hematopathological finding of an inclusion arising from detached DNA nuclear fragment in white blood cells caused by dysplastic granulopoiesis. [1] The inclusion is aptly named for its similar appearance of the Howell–Jolly body in erythrocytes. [2] The term was coined in 1989. [2]
Theodor Boveri originally observed the fact that abnormal nuclear morphologies commonly occur in cancer.Micronuclei are also referred to Howell-Jolly bodies; discovered by hematologists William Henry Howell and Justin Marie Jolly in erythrocytes.
Partial splenectomy: Since the spleen is important for protecting against encapsulated organisms, sepsis caused by encapsulated organisms is a possible complication of splenectomy. [7] The option of partial splenectomy may be considered in the interest of preserving immune function. Research on outcomes is currently limited, [7] but favorable. [8]
He’d tried 12-step and abstinence-only programs three times, but each attempt at recovery had ended in relapse. The public health establishment, including the National Institute on Drug Abuse and the World Health Organization , has said that medications like buprenorphine (and methadone), when coupled with counseling, give people with opioid ...
A degmacyte or bite cell is an abnormally shaped mature red blood cell with one or more semicircular portions removed from the cell margin, known as "bites". [1] [2] These "bites" result from the mechanical removal of denatured hemoglobin during splenic filtration as red cells attempt to migrate through endothelial slits from splenic cords into the splenic sinuses. [3]