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The Human Protein Atlas contains information about the human proteins in cells, tissues, and organs. All the data in the knowledge resource is open access to allow scientists both in academia and industry to freely access the data for exploration of the human proteome.
Proteogenomics uses an integrated approach by combining genomics, proteomics, and transcriptomics.. Proteogenomics is a field of biological research that utilizes a combination of proteomics, genomics, and transcriptomics to aid in the discovery and identification of peptides.
The human interactome is the set of protein–protein interactions (the interactome) that occur in human cells. [ 1 ] [ 2 ] The sequencing of reference genomes, in particular the Human Genome Project , has revolutionized human genetics , molecular biology , and clinical medicine .
The Human Proteome Project [1] (HPP) is a collaborative effort coordinated by the Human Proteome Organization. [2] Its stated goal is to experimentally observe all of the proteins produced by the sequences translated from the human genome .
Human Proteinpedia, which is closely associated with Institute of Bioinformatics (IOB), Bangalore and Johns Hopkins University, is a portal for sharing and integration of human proteomic data. [ 1 ] [ 2 ] It allows research laboratories to contribute and maintain protein annotations.
In selected human malignancies such as acute myeloid leukemia, allogeneic hematopoietic cell transplantations have shown that the development of donor NK cells in recipient patients lacking donor KIR ligands can lead to improved engraftment and post-transplant survival by boosting graft-versus-leukemia effect in the absence of graft-versus-host ...
The GPI-anchored cell surface protein glypican-3 (GPC3) is known to interact with Fat1 in human liver cancer. [19] GPC3 is also shown to modulate Yap signaling in liver cancer. [ 20 ] While Fat is known to bind to another atypical cadherin, Dachsous (Ds), during tissue patterning, [ 21 ] it is unclear what role Ds has in regulating tissue growth.
CAPZB is a member of the F-actin capping protein family. This gene encodes the beta subunit of the barbed-end actin binding protein. The protein regulates growth of the actin filament by capping the barbed end of growing actin filaments.