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A cancer syndrome or family cancer syndrome is a genetic disorder in which inherited genetic mutations in one or more genes predisposes the affected individuals to the development of cancers and may also cause the early onset of these cancers. Although cancer syndromes exhibit an increased risk of cancer, the risk varies.
Extracts from Camptotheca (the "happy tree" or "cancer tree") were used to develop the chemotherapeutic drug Topotecan. Plant sources of anti-cancer agents are plants, the derivatives of which have been shown to be usable for the treatment or prevention of cancer in humans. [1] [2]
Although a DNA repair deficiency can predispose a cell lineage to develop cancer, increased (rather than decreased) expression of a repair capability may also emerge in the progression of cancer cell lineages, and this capability may be clinically important as reviewed by Lingg et al. [9] For instance, the DNA repair gene DMC1 encodes a protein ...
The central role of DNA damage and epigenetic defects in DNA repair genes in carcinogenesis. DNA damage is considered to be the primary cause of cancer. [17] More than 60,000 new naturally-occurring instances of DNA damage arise, on average, per human cell, per day, due to endogenous cellular processes (see article DNA damage (naturally occurring)).
doi: 10.1377/hlthaff.2011.0077 HEALTH AFFAIRS 30, NO. 5 (2011): 852–862 ©2011 Project HOPE— The People-to-People Health Foundation, Inc. Paul Mohai(pmohai@umich.edu) is a professor in the School of Natural Resources and Environment and a faculty associate at the Institute for Social Research, both at the University of Michigan, in Ann Arbor.
Lighter damage may leave a stable, partly functional cell that may be capable of proliferating and eventually developing into cancer, especially if tumor suppressor genes are damaged. [6] [31] [32] [33] The latest research suggests that mutagenic events do not occur immediately after irradiation. Instead, surviving cells appear to have acquired ...
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There are several case reports of spontaneous regressions from cancer occurring after a fever brought on by infection, [2] [6] suggesting a possible causal connection. If this coincidence in time would be a causal connection, it should as well precipitate as prophylactic effect, i.e. feverish infections should lower the risk to develop cancer ...