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A nucleated red blood cell (NRBC), also known by several other names, is a red blood cell that contains a cell nucleus. Almost all vertebrate organisms have hemoglobin -containing cells in their blood, and with the exception of mammals , all of these red blood cells are nucleated. [ 1 ]
In the process of erythropoiesis (red blood cell formation), reticulocytes develop and mature in the bone marrow and then circulate for about a day in the blood stream before developing into mature red blood cells. Like mature red blood cells, in mammals, reticulocytes do not have a cell nucleus.
As red blood cells contain no nucleus, protein biosynthesis is currently assumed to be absent in these cells. Because of the lack of nuclei and organelles, mature red blood cells do not contain DNA and cannot synthesize any RNA (although it does contain RNAs), [57] [58] and consequently cannot divide and have limited repair capabilities. [59]
The normal RBCs count is 4.5 to 5 millions per cu.mm. RBCs have a lifespan of approximately 100-120 days. After they have completed their lifespan, they are removed from the bloodstream by the spleen. Mature red blood cells are unique among cells in the human body in that they lack a nucleus (although erythroblasts do have a nucleus).
Cell nucleus: A cell's information center, the cell nucleus is the most conspicuous organelle found in a eukaryotic cell. It houses the cell's chromosomes , and is the place where almost all DNA replication and RNA synthesis ( transcription ) occur.
The cell nucleus (from Latin nucleus or nuculeus 'kernel, seed'; pl.: nuclei) is a membrane-bound organelle found in eukaryotic cells.Eukaryotic cells usually have a single nucleus, but a few cell types, such as mammalian red blood cells, have no nuclei, and a few others including osteoclasts have many.
The average lifespan of a red blood cell is approximately 120 days. During this maturation process, there is nuclear extrusion – i.e. mature erythrocytes have no nucleus. Nucleated red blood cells present in a sample of bone marrow can indicate the release of incompletely developed cells.
4.7 to 6.1 million (male), 4.2 to 5.4 million (female) erythrocytes: [13] Red blood cells contain the blood's hemoglobin and distribute oxygen. Mature red blood cells lack a nucleus and organelles in mammals. The red blood cells (together with endothelial vessel cells and other cells) are also marked by glycoproteins that define the different ...