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  2. Adult neurogenesis - Wikipedia

    en.wikipedia.org/wiki/Adult_neurogenesis

    While the exact nature of the relationship between neurogenesis and Alzheimer's disease is unknown, insulin-like growth factor 1-stimulated neurogenesis produces major changes in hippocampal plasticity and seems to be involved in Alzheimer's pathology. [79] Allopregnanolone, a neurosteroid, aids the continued neurogenesis in the brain.

  3. Neurogenesis - Wikipedia

    en.wikipedia.org/wiki/Neurogenesis

    Neurogenesis is the process by which nervous system cells, the neurons, are produced by neural stem cells (NSCs). [1] This occurs in all species of animals except the porifera (sponges) and placozoans . [ 2 ]

  4. Neurobiological effects of physical exercise - Wikipedia

    en.wikipedia.org/wiki/Neurobiological_effects_of...

    Neuroplasticity is the process by which neurons adapt to a disturbance over time, and most often occurs in response to repeated exposure to stimuli. [27] Aerobic exercise increases the production of neurotrophic factors [note 1] (e.g., BDNF, IGF-1, VEGF) which mediate improvements in cognitive functions and various forms of memory by promoting blood vessel formation in the brain, adult ...

  5. Environmental enrichment - Wikipedia

    en.wikipedia.org/wiki/Environmental_enrichment

    Decreased hippocampal neurogenesis is a characteristic of aging. Environmental enrichment increases neurogenesis in aged rodents by potentiating neuronal differentiation and new cell survival. [57] As a result, subjects exposed to environmental enrichment aged better due to superior ability in retaining their levels of spatial and learning ...

  6. Brain-derived neurotrophic factor - Wikipedia

    en.wikipedia.org/wiki/Brain-derived_neurotrophic...

    Knockout mice also exhibit cerebellar abnormalities and an increase in the number of sympathetic neurons. [22] Certain types of physical exercise have been shown to markedly (threefold) increase BDNF synthesis in the human brain, a phenomenon which is partly responsible for exercise-induced neurogenesis and improvements in cognitive function.

  7. Epigenetic regulation of neurogenesis - Wikipedia

    en.wikipedia.org/wiki/Epigenetic_regulation_of...

    Neurogenesis continues after development well through adulthood. [2] Growth arrest and DNA-damage-inducible, beta (GADD45b) is required for the demethylation of promoters of critical genes responsible for new-born neuron development such as brain-derived neurotrophic factor (BDNF) and basic fibroblast growth factor (FGF2). [8]

  8. Neuroregeneration - Wikipedia

    en.wikipedia.org/wiki/Neuroregeneration

    Guillain–Barré syndrome – nerve damage. Neuroregeneration in the peripheral nervous system (PNS) occurs to a significant degree. [5] [6] After an injury to the axon, peripheral neurons activate a variety of signaling pathways which turn on pro-growth genes, leading to reformation of a functional growth cone and regeneration.

  9. Brian Christie (neuroscientist) - Wikipedia

    en.wikipedia.org/wiki/Brian_Christie...

    Together these individuals published four influential publications on adult hippocampal neurogenesis, with Christie performing the majority of the electrophysiological recordings. Christie's research has shown that exercise promotes adult neurogenesis and synaptic plasticity in the hippocampus. [4] [5]

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