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The artery supplies the anterior region of the left ventricle, including: the anterolateral myocardium, apex, anterior interventricular septum, and anterolateral papillary muscle. [8] The LAD typically supplies 45–55% of the left ventricle and is therefore considered the most critical vessel in terms of myocardial blood supply. [citation needed]
In the original Wellens' study group, 75% of those with the typical syndrome manifestations had an anterior myocardial infarction. Sensitivity and specificity for significant (more or equal to 70%) stenosis of the LAD artery was found to be 69% and 89%, respectively, with a positive predictive value of 86%.
It can be seen in approximately 4% of cases of acute myocardial infarction [citation needed] It is the most common type of intraventricular conduction defect seen in acute anterior myocardial infarction, and the left anterior descending artery is usually the culprit vessel. It can be seen with acute inferior wall myocardial infarction.
12-lead electrocardiogram showing ST-segment elevation (orange) in I, aVL and V1–V5 with reciprocal changes (blue) in the inferior leads, indicative of an anterior wall myocardial infarction. When there is a blockage of the coronary artery , there will be lack of oxygen supply to all three layers of cardiac muscle (transmural ischemia).
The hexaxial reference system is a diagram that is used to determine the heart's electrical axis in the frontal plane.. In electrocardiography, left axis deviation (LAD) is a condition wherein the mean electrical axis of ventricular contraction of the heart lies in a frontal plane direction between −30° and −90°.
A myocardial infarction (MI), commonly known as a heart attack, occurs when blood flow decreases or stops in one of the coronary arteries of the heart, causing infarction (tissue death) to the heart muscle. [1] The most common symptom is retrosternal chest pain or discomfort that classically radiates to the left shoulder, arm, or jaw. [1]
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In particular, acute myocardial infarction in the distribution of the circumflex artery is likely to produce a nondiagnostic ECG. [10] The use of additional ECG leads like right-sided leads V3R and V4R and posterior leads V7, V8, and V9 may improve sensitivity for right ventricular and posterior myocardial infarction. [citation needed]