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Not all women with PCOS have difficulty becoming pregnant. For those who do, anovulation is a common cause. The mechanism of this anovulation is uncertain, but there is evidence of arrested antral follicle development, which, in turn, may be caused by abnormal interaction of insulin and luteinizing hormone (LH) on granulosa cells.
"Women with PCOS have a tendency toward insulin resistance, which can make it harder to ovulate," Dr. Sekhon explains. "Reducing weight can help lessen insulin resistance and restore normal ovulation.
PCOS is the most common endocrine disorder among women between the ages of 18 and 44. [24] It affects approximately 2% to 20% of this age group depending on how it is defined. [8] [13] When someone is infertile due to lack of ovulation, PCOS is the most common cause and could guide to patients' diagnosis. [4]
It is in fact possible to restore ovulation using appropriate medication, and ovulation is successfully restored in approximately 90% of cases. The first step is the diagnosis of anovulation. The identification of anovulation is not easy; contrary to what is commonly believed, women undergoing anovulation still have (more or less) regular periods.
In other words, people with PCOS have ovaries that may release eggs infrequently, become enlarged with many fluid-filled sacs containing immature eggs (called follicles) or make too many androgens ...
When ovulation doesn’t happen, the ovaries can develop many small fluid-filled sacs (cysts). ... Tang points to statistics that say 50 to 75% of people with PCOS will deal with either insulin ...
And many people are simply choosing to have less children, or no children at all. ... It is also associated with polycystic ovary syndrome, or PCOS, which causes irregular ovulation, the opinion ...
As the negative feedback of estrogen is inhibited, the hypothalamus secretes GnRh which in turn stimulates the anterior pituitary to secrete LH and FSH which help in ovulation. Between 60 and 85% of women, mostly with polycystic ovary syndrome (PCOS), ovulate successfully in response to clomiphene with a cumulative pregnancy rate of 30 to 40%.
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