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[43] [44] Prolonged-release melatonin is safe with long-term use of up to 12 months. [11] Although not recommended for long-term use beyond this, [45] low-dose melatonin is generally safer, and a better alternative, than many prescription and over-the-counter sleep aids if a sleeping medication must be used for an extended period of time.
Long-term use of the pill form may cause adrenal insufficiency. [16] Stopping the pills suddenly following long-term use may therefore be dangerous. [16] The inhaled form is generally safe in pregnancy. [16] Budesonide chiefly acts as a glucocorticoid. [16] Budesonide was initially patented in 1973. [17]
Long-term use is sometimes described as use not shorter than three months. [2] Benzodiazepines are generally effective when used therapeutically in the short term, [3] but even then the risk of dependency can be significantly high. There are significant physical, mental and social risks associated with the long-term use of benzodiazepines. [3]
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[1] [2] Acorns are 1–6 cm (1 ⁄ 2 – 2 + 1 ⁄ 2 in) long and 0.8–4 cm (3 ⁄ 8 – 1 + 5 ⁄ 8 in) on the fat side. Acorns take between 5 and 24 months (depending on the species) to mature; see the list of Quercus species for details of oak classification, in which acorn morphology and phenology are important factors.
Minoxidil, when used for hypertension, is generally reserved for use in severe hypertension patients who do not respond to at least two agents and a diuretic. [13] Minoxidil is also generally administered with a loop diuretic to prevent sodium and potassium retention. [13] It may also cause a reflex tachycardia and thus is prescribed with a ...
Common side effects with long-term use include bone loss, weakness, yeast infections, and easy bruising. [6] While short-term use in the later part of pregnancy is safe, long-term use or use in early pregnancy is occasionally associated with harm to the baby. [1] It is a glucocorticoid made from hydrocortisone . [10]
Trazodone, sold under many brand names, [1] is an antidepressant medication, [20] used to treat major depressive disorder, anxiety disorders, and insomnia. [20] It is a phenylpiperazine compound of the serotonin antagonist and reuptake inhibitor (SARI) class.