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Interferon gamma (IFNG or IFN-γ) is a dimerized soluble cytokine that is the only member of the type II class of interferons. [5] The existence of this interferon, which early in its history was known as immune interferon, was described by E. F. Wheelock as a product of human leukocytes stimulated with phytohemagglutinin, and by others as a product of antigen-stimulated lymphocytes. [6]
C-X-C motif chemokine ligand 10 (CXCL10) also known as Interferon gamma-induced protein 10 (IP-10) or small-inducible cytokine B10 is an 8.7 kDa protein that in humans is encoded by the CXCL10 gene. [ 5 ] [ 6 ] C-X-C motif chemokine 10 is a small cytokine belonging to the CXC chemokine family.
He later won the Nobel Prize in chemistry. Interferon was scarce and expensive until 1980, when the interferon gene was inserted into bacteria using recombinant DNA technology, allowing mass cultivation and purification from bacterial cultures [84] or derived from yeasts. Interferon can also be produced by recombinant mammalian cells. [85]
They include interleukin-1 (IL-1), IL-6, IL-12, and IL-18, tumor necrosis factor alpha (TNF-α), interferon gamma (IFNγ), and granulocyte-macrophage colony stimulating factor (GM-CSF) and play an important role in mediating the innate immune response. Inflammatory cytokines are predominantly produced by and involved in the upregulation of ...
CD8 + T C 1 Cells. These cells generally produce interferon gamma. Interferon gamma and IL-12 promote differentiation toward T C 1 cells. T-bet activation is required for both interferon gamma and cytolytic potential. CCR5 and CXCR3 are the main chemokine receptors for this cell. [5] Group 1 ILCs. Groups 1 ILCs are defined to include ILCs ...
[1] [4] The receptor is coded for by number of different genes, due to the diversity of types of interferons. Regulation of cell surface receptor levels plays an important role in the regulation and limiting of interferon signaling. interferon-alpha/beta receptor; interferon-gamma receptor; Interferon type III receptor
The background: SMU, at 11-1 and riding a nine-game winning streak into the Atlantic Coast Conference title game, was slotted at No. 8 in Tuesday night's latest ranking. Iowa State, meanwhile, is ...
3440 15965 Ensembl ENSG00000188379 ENSMUSG00000078354 UniProt P01563 P01573 RefSeq (mRNA) NM_000605 NM_010503 RefSeq (protein) NP_000596 NP_034633 Location (UCSC) Chr 9: 21.38 – 21.39 Mb Chr 4: 88.6 – 88.6 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Interferon alpha-2 is a protein that in humans is encoded by the IFNA2 gene. Protein family Human interferon alpha-2 (IFNα2) is ...