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These diverticula make their appearance before the closure of the anterior end of the neural tube; [1] [2] after the closure of the tube around the 4th week of development, they are known as the optic vesicles. Previous studies of optic vesicles suggest that the surrounding extraocular tissues – the surface ectoderm and extraocular mesenchyme ...
The optic vesicles project toward the sides of the head, and the peripheral part of each expands to form a hollow bulb, while the proximal part remains narrow and constitutes the optic stalk. [1] [2] Closure of the choroidal fissure in the optic stalk occurs during the seventh week of development. The former optic stalk is then called the optic ...
Sclerocornea is a rare disorder, with no clear gender bias. In one study, 14 patients were diagnosed with a congenital corneal opacity over a 40-year study period, yielding a birth prevalence of 1 in 5188 live births. The mean age at diagnosis was 7.5 months (range 0–48 months) and 9 (64.3%) were males.
The optic vesicles then develop into the optic cup with the inner layer forming the retina and the outer portion forming the retinal pigment epithelium. The middle portion of the optic cup develops into the ciliary body and iris. [7] During the invagination of the optic cup, the ectoderm begins to thicken and form the lens placode, which ...
The optical vesicle (which eventually becomes the optic nerve, retina and iris) forms at the basal plate of the prosencephalon. The alar plate of the prosencephalon expands to form the cerebral hemispheres (the telencephalon) whilst its basal plate becomes the diencephalon. Finally, the optic vesicle grows to form an optic outgrowth.
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Optic pits are associated with other abnormalities of the optic nerve including large optic nerve size, large inferior colobomas of the optic disc, and colobomas of the retina. The optic disc originates from the optic cup when the optic vesicle invaginates and forms an embryonic fissure (or groove). Optic pits may develop due to failure of the ...