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The disorder can cause heart abnormalities and seizures if the amount of methemoglobin in the blood exceeds 20 percent, but at levels between 10 and 20 percent it can cause blue skin without other symptoms. Most of the Fugates lived long and healthy lives. The "bluest" of the blue Fugates, Luna Stacy, had 13 children and lived to age 84. [6]
The Fugates, a family that lived in the hills of Kentucky in the US, had the hereditary form. They are known as the "Blue Fugates". [ 30 ] Martin Fugate and Elizabeth Smith, who had married and settled near Hazard, Kentucky , around 1800, were both carriers of the recessive methemoglobinemia (met-H) gene, as was a nearby clan with whom the ...
The most dramatic symptom of argyria is that the skin turns blue or blue-gray. It may take the form of generalized argyria or local argyria. Generalized argyria affects large areas over much of the visible surface of the body. Local argyria shows in limited regions of the body, such as patches of skin, parts of the mucous membrane or the ...
Paul Karason (November 14, 1950 – September 23, 2013) was an American from Bellingham, Washington, whose skin was a purple-blue color. [ 1 ] Karason was fair skinned and freckled until the early 1990s.
Blue people may refer to: Methemoglobinemia, a disorder that can turn skin blue the Blue Fugates, an Appalachian family with congenital methemoglobinemia; Cyanosis, a general medical condition that can turn skin blue Blue baby syndrome, cyanosis in babies; A name for the Tuareg people, from their traditional clothing
The structure of cytochrome b5 reductase, the enzyme that converts methemoglobin to hemoglobin. [1]Methemoglobin (British: methaemoglobin, shortened MetHb) (pronounced "met-hemoglobin") is a hemoglobin in the form of metalloprotein, in which the iron in the heme group is in the Fe 3+ state, not the Fe 2+ of normal hemoglobin.
It is not fear but exposure that causes moral injury – an experience or set of experiences that can provoke mild or intense grief, shame and guilt. The symptoms are similar to PTSD: depression and anxiety, difficulty paying attention, an unwillingness to trust anyone except fellow combat veterans.
Do not merge this entry with the entry on the Blue Fugates of Appalachia - continue to provide links and cross-references between the two articles. The Blue Fugate entry has the potential to be expanded as a family history, with many details outside the scope of a general overview of methemoglobinemia.