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Photo showing the sclerokeratitis associated with GPA within the arterial wall or; in the perivascular area; According to the Chapel Hill Consensus Conference (CHCC) on the nomenclature of systemic vasculitis (1992), establishing the diagnosis of GPA demands: [22] a granulomatous inflammation involving the respiratory tract, and
Tumors, medications, allergic reactions, and infectious organisms are some of the recognized triggers for these conditions, even though the precise cause of many of them is unknown. Immune complex disease, anti-neutrophil cytoplasmic antibodies , anti-endothelial cell antibodies, and cell-mediated immunity are examples of pathogenetic factors.
Vasculitis frequently coexists with infections, and several infections, including hepatitis B and C, HIV, infective endocarditis, and tuberculosis, are significant secondary causes of vasculitis. [35] Except for rheumatoid vasculitis, the majority of secondary vasculitis forms are exceedingly rare. [36]
Clinical features may include constitutional symptoms like fever, arthralgia, myalgia, loss of appetite, weight loss and fatigue.A variety of organs can be affected, which causes a wide range of symptoms such as cough, shortness of breath, hemoptysis (coughing up of blood), symptoms of kidney failure, skin manifestations (palpable purpura and livedo racemosa [1]), seizures or peripheral ...
Cerebral vasculitis (sometimes the word angiitis is used instead of "vasculitis") is vasculitis (inflammation of the blood vessel wall) involving the brain and occasionally the spinal cord. [1] It affects all of the vessels: very small blood vessels ( capillaries ), medium-size blood vessels ( arterioles and venules ), or large blood vessels ...
Eosinophilic granulomatosis with polyangiitis consists of three stages, but not all patients develop all three stages or progress from one stage to the next in the same order; [7] whereas some patients may develop severe or life-threatening complications such as gastrointestinal involvement and heart disease, some patients are only mildly affected, e.g. with skin lesions and nasal polyps. [8]
Nervous system conditions and neurological issues that can cause nerve damage include stroke, multiple sclerosis, and diabetic neuropathy. A spinal cord injury or pinched nerve may also lead to ...
Treatment should be directed towards the specific underlying cause of the vasculitis. If no underlying cause is found and the vasculitis is truly limited to the skin then treatment is primarily supportive. [13] Such treatment involves measures such as leg elevation, stockings, and topical steroids to relieve itching/burning. If the vasculitis ...