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Norethisterone is a substrate for and is known to be an inhibitor of 5α-reductase, with 4.4% and 20.1% inhibition at 0.1 and 1 μM, respectively. [11] However, therapeutic concentrations of norethisterone are in the low nanomolar range, so this action may not be clinically relevant at typical dosages. [11]
Norethisterone and ethinylestradiol levels over 24 hours after a single oral dose of 10 mg NETA in postmenopausal women. [ 25 ] NETA metabolizes into ethinylestradiol at a rate of 0.20 to 0.33% across a dose range of 10 to 40 mg. [ 26 ] [ 27 ] Peak levels of ethinylestradiol with a 10, 20, or 40 mg dose of NETA were 58, 178, and 231 pg/mL ...
Formulations and brand names of norethisterone and esters Composition Dose Brand names Use NET only: Low (e.g., 0.35 mg) Multiple [a] Progestogen-only oral contraceptive: NET or NETA only: High (e.g., 5 mg, 10 mg) Multiple [b] Gynecological disorders and other uses NETE only: Injection (e.g., 200 mg) Multiple [c] Progestogen-only injectable ...
nanomolar 10 9 M GM gigamolar 10 −12 M pM picomolar 10 12 M TM teramolar 10 −15 M fM femtomolar 10 15 M PM petamolar 10 −18 M aM attomolar 10 18 M EM examolar 10 −21 M zM zeptomolar 10 21 M ZM zettamolar 10 −24 M yM yoctomolar 10 24 M YM yottamolar 10 −27 M rM rontomolar 10 27 M RM ronnamolar 10 −30 M qM quectomolar 10 30 M QM
Unlike norethisterone which is purely progestogenic, 5α-DHNET has been found to possess both progestogenic and marked antiprogestogenic activity, showing a profile of progestogenic activity like that of a selective progesterone receptor modulator (SPRM). [4]
More than 38 million Americans have diabetes, and between 90% and 95% of them have type 2 diabetes. While most are adults over the age of 45, an increasing number of children and teens are also ...
NETE is a prodrug of norethisterone in the body. [13] Upon reaching circulation, it is rapidly converted into norethisterone by esterases.Hence, as a prodrug of norethisterone, NETE has essentially the same effects as norethisterone, acting as a potent progestogen with additional weak androgenic and estrogenic activity (the latter via its metabolite ethinylestradiol). [14]
On a chilly day, there’s nothing more comforting than curling up under a cozy blanket with a warm cup of tea. But tea offers much more than just comfort and hydration in cold weather.