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Equine EPM is caused by the parasites that exhibit SAG1, SAG5, and SAG6. SAG1 and SAG5 are responsible for the majority of EPM cases in horses. Horses produce antibodies to these surface antigens. Serum antibody testing is available that measures levels of these antibodies in the blood of horses, which is helpful in diagnosing EPM in an ataxic ...
Ponazuril (), sold by Merial, Inc., [1] now part of Boehringer Ingelheim, [2] under the trade name Marquis (15% w/w ponazuril), is a drug currently approved for the treatment of equine protozoal myeloencephalitis (EPM) in horses, caused by coccidia Sarcocystis neurona.
Neospora hughesi is an obligate protozoan apicomplexan parasite that causes myelitis and equine protozoal myeloencephalitis (EPM) in horses, and has only been documented in North America. [1] EPM is a neurological disease from lesions in the spinal cord , brain stem , or brain from parasites such as N. hughesi or Sarcocystis neurona . [ 2 ]
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Affected horses should additionally be placed on a dose of 1.0 mg/kg pyrimethamine orally for 120 days or longer. Other coccidiostats are currently being evaluated to treat EPM. Recommended measures of prevention include proper hygiene and preventing opossums to horse feed and horse grazing pastures.
The feet should be cleaned every time the horse is ridden, and if the horse is not ridden, it is still best practice to check and clean feet frequently. Daily cleaning is recommended in many management books, though if horses are on turnout and not being ridden, a weekly hoof check of healthy horses is often sufficient during good weather.
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