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Nortriptyline is an active metabolite of amitriptyline by demethylation in the liver. Chemically, it is a secondary amine dibenzocycloheptene and pharmacologically it is classed as a first-generation antidepressant. [36] Nortriptyline may also have a sleep-improving effect due to antagonism of the H 1 and 5-HT 2A receptors. [37]
A systematic review published in the journal Obesity Reviews in 2019 found that just about all of the widely-used medications for depression resulted in long-term weight gain, with the exception ...
The nortriptyline group experienced moderate weight gain. However, antidepressants don’t affect everyone equally, so there could still be a link between Lexapro and weight changes or other SSRIs ...
“Just as much as the GLP-1s are a diabetes drug and a weight loss medicine, they are brain drugs, too,” says Rekha Kumar, MD, an endocrinologist at New York-Presbyterian and Weill Cornell ...
Thyroid hormones, another early weight loss drug, also raised energy expenditure but ceased to be used for weight loss due to cardiac risks and other adverse effects. [18] Selective thyromimetics that work on the thyroid hormone receptor beta may be able to exert some of the beneficial thermogenic effects of thyroid hormones with fewer adverse ...
Dieting is the practice of eating food in a regulated way to decrease, maintain, or increase body weight, or to prevent and treat diseases such as diabetes and obesity.As weight loss depends on calorie intake, different kinds of calorie-reduced diets, such as those emphasising particular macronutrients (low-fat, low-carbohydrate, etc.), have been shown to be no more effective than one another.
How much sleep you get can affect your weight loss journey and even cause weight gain for some people. The CDC recommends adults get 7 to 9 hours of sleep each night. Consider weight loss medications.
Therefore I think this part "Nortriptyline has poor long-term efficacy with a high relapse rate in individuals being treated for depression, possibly due to a toxic metabolite 10-hydroxynortriptyline, being produced.