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The human mitochondrial genome is the entirety of hereditary information contained in human mitochondria. Mitochondria are small structures in cells that generate energy for the cell to use, and are hence referred to as the "powerhouses" of the cell. Mitochondrial DNA (mtDNA) is not transmitted through nuclear DNA (nDNA).
English: Map of the human mitochondrial DNA genome (16569 bp, NCBI sequence accession NC_012920 — Anderson et al. 1981). The H (heavy, outer circle) and L (light, inner circle) strands are given with their corresponding genes.
Mitochondrial DNA is the small circular chromosome found inside mitochondria. ... (see the human mitochondrial genome map). During transcription, the tRNAs acquire ...
[1] (a) Pie charts on the map. (b) Counts of haplogroups in table format. For populations details, see 1000 Genomes Project#Human genome samples. In human genetics, a human mitochondrial DNA haplogroup is a haplogroup defined by differences in human mitochondrial DNA. Haplogroups are used to represent the major branch points on the ...
Haplogroup R is a widely distributed human mitochondrial DNA (mtDNA) haplogroup. Haplogroup R is associated with the peopling of Eurasia after about 70,000 years ago, and is distributed in modern populations throughout the world outside of sub-Saharan Africa. [4] Haplogroup R is a descendant of the macro-haplogroup N.
A group led by Fred Sanger at the University of Cambridge had sequenced the mitochondrial genome of one woman of European descent [3] during the 1970s, determining it to have a length of 16,569 base pairs (0.0006% of the nuclear human genome) containing some 37 genes and published this sequence in 1981. [2]
The mtDNA control region is an area of the mitochondrial genome which is non-coding DNA. This region controls RNA and DNA synthesis. [1] It is the most polymorphic region of the human mtDNA genome, [2] with polymorphism concentrated in hypervariable regions. The average nucleotide diversity in these regions is 1.7%. [3]
However, the extant diversity of mitochondrial genomes that belong to Haplogroup A is low relative to the degree of divergence from its nearest outgroups in haplogroup N, which suggests that extant members of Haplogroup A might be descended from a population that has emerged from a bottleneck approximately 20,000 years ago.