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  2. meta-Chlorophenylpiperazine - Wikipedia

    en.wikipedia.org/wiki/Meta-Chlorophenylpiperazine

    [2] [51] [52] The elimination half-life of mCPP is 4 to 14 hours. [2] mCPP is a metabolite of a variety of other piperazine drugs including trazodone, nefazodone, etoperidone, enpiprazole, mepiprazole, cloperidone, peraclopone, and BRL-15,572. [52] [additional citation(s) needed] It is formed by dealkylation via CYP3A4. [52]

  3. Trazodone - Wikipedia

    en.wikipedia.org/wiki/Trazodone

    Trazodone has a minor active metabolite known as meta-chlorophenylpiperazine (mCPP), and this metabolite may contribute to some degree to the pharmacological properties of trazodone. [11] [110] In contrast to trazodone, mCPP is an agonist of various serotonin receptors. [111]

  4. Substituted piperazine - Wikipedia

    en.wikipedia.org/wiki/Substituted_piperazine

    Trazodone, nefazodone, mepiprazole, and others produce mCPP as a metabolite. para-Substituted. 4-Chlorophenylpiperazine (pCPP) 4-Fluorophenylpiperazine (pFPP)

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  6. Serotonin antagonist and reuptake inhibitor - Wikipedia

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    These drugs act as antagonists or inverse agonists of the 5-HT 2A, α 1-adrenergic, and H 1 receptors, as partial agonists of the 5-HT 1A receptor, [3] and as inhibitors of the transporters. mCPP is an antagonist of the 5-HT 2B receptor, an agonist of the 5-HT 1A, [3] 5-HT 2C, and 5-HT 3 receptors, [4] [5] and acts as a partial agonist of the ...

  7. What is Compounded Tirzepatide? Here's What You Need to Know

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    Making a liquid form of a medication for those who can’t swallow tablets Changing the dose strengths or diluting them to suit an individual’s need Making a different version if there are drug ...

  8. A Cold War-era bomb shelter in Florida has new owners. What's ...

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    Residents near a Cold War-era nuclear bomb shelter are wondering what the property's new owners are doing on the other side of the chain-link fence topped by barbed wire. ... Get sweaters on sale ...

  9. Zepbound Weight Loss Medication Approved by FDA to Treat ...

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    The weight loss drug Zepbound, generically known as tirzepatide, is also now an approved medication to treat obstructive sleep apnea, per a Food and Drug Administration Dec. 20 press release.. The ...

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