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  2. Corepressor - Wikipedia

    en.wikipedia.org/wiki/Corepressor

    In genetics and molecular biology, a corepressor is a molecule that represses the expression of genes. [1] In prokaryotes , corepressors are small molecules whereas in eukaryotes , corepressors are proteins .

  3. Coactivator (genetics) - Wikipedia

    en.wikipedia.org/wiki/Coactivator_(genetics)

    Many coactivators have histone acetyltransferase (HAT) activity meaning that they can acetylate specific lysine residues on the N-terminal tails of histones. [ 4 ] [ 7 ] [ 11 ] In this method, an activator binds to an enhancer site and recruits a HAT complex that then acetylates nucleosomal promoter-bound histones by neutralizing the positively ...

  4. Transcription coregulator - Wikipedia

    en.wikipedia.org/wiki/Transcription_coregulator

    corepressor – a protein (or a small molecule) that works with transcription factors to decrease the rate of gene transcription response element – a specific sequence of DNA that a transcription factor binds to

  5. Nuclear receptor coregulators - Wikipedia

    en.wikipedia.org/wiki/Nuclear_receptor_coregulators

    The ability of nuclear receptors to alternate between activation and repression in response to specific molecular cues, is now known to be attributable in large part to a diverse group of cellular factors, collectively termed coregulators and including coactivators and corepressors.

  6. Transcription factor - Wikipedia

    en.wikipedia.org/wiki/Transcription_factor

    corepressor – a protein (or a small molecule) that works with transcription factors to decrease the rate of gene transcription response element – a specific sequence of DNA that a transcription factor binds to

  7. Silencer (genetics) - Wikipedia

    en.wikipedia.org/wiki/Silencer_(genetics)

    Furthermore, the NRSF-NRSE complex recruits a transcriptional corepressor known as mSin3. [13] This leads to the activity of histone deacetylase in the region and the repression of the gene. Therefore, studies have revealed the correlation between REST/NRSF and RE1/NRSE in regulating the ANP gene expression in ventricular myocytes. A mutation ...

  8. CTBP1 - Wikipedia

    en.wikipedia.org/wiki/CTBP1

    The CtBP1 protein was originally identified as a human protein that bound a PLDLS motif in the C-terminus of adenovirus E1A proteins. It and the related protein CTBP2 were later shown to function as transcriptional corepressors. [7]

  9. BCL-6 corepressor - Wikipedia

    en.wikipedia.org/wiki/BCL-6_corepressor

    BCL-6 corepressor is a protein that in humans is encoded by the BCOR gene. [5] [6] Function