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The cause of CIN is chronic infection of the cervix with HPV, especially infection with high-risk HPV types 16 or 18. It is thought that the high-risk HPV infections have the ability to inactivate tumor suppressor genes such as the p53 gene and the RB gene, thus allowing the infected cells to grow unchecked and accumulate successive mutations, eventually leading to cancer.
The Papanicolaou test (abbreviated as Pap test, also known as Pap smear (AE), [1] cervical smear (BE), cervical screening (BE), [2] or smear test (BE)) is a method of cervical screening used to detect potentially precancerous and cancerous processes in the cervix (opening of the uterus or womb) or, more rarely, anus (in both men and women). [3]
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This would send the simulated virtual person with diabetes ('Joy Wilson' [pseudonym]) markedly hyperglycemic in the afternoon (with a predicted blood glucose level of 18.8 mmol/L [338 mg/dL] at 2:30pm) — and leave her at significant risk of developing diabetic ketoacidosis. The simulated blood glucose profile is shown in the upper graph, and ...
The diagnosis is generally based on symptoms and supported by a lithium level in blood serum of greater than 1.2 mEq/L. [1] [2] Gastric lavage and whole bowel irrigation may be useful if done early. [1] Activated charcoal is not effective. [1] For severe toxicity hemodialysis is recommended. [1] The risk of death is generally low. [3]
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Plasma cell leukemia (PCL) is a plasma cell dyscrasia, i.e. a disease involving the malignant degeneration of a subtype of white blood cells called plasma cells.It is the terminal stage and most aggressive form of these dyscrasias, constituting 2% to 4% of all cases of plasma cell malignancies.