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The drug is placed within the medium in the vessels after it has reached sufficient temperature and then the dissolution apparatus is operated. Sample solutions collected from dissolution testing are commonly analyzed by HPLC or Ultraviolet–visible spectroscopy. [27]
During the dissolution testing, "sink condition" is a mandatory requirement, otherwise when the concentration begins to get too close to the saturation point, even though the total soluble amount still remains constant, the dissolution rate will gradually begin to reduce in significant amounts, enough to corrupt the test results. . [2] [3] [4]
The contents of the USP Dissolution Apparatus 2 page were merged into Dissolution testing on 02/15/2017. For the contribution history and old versions of the redirected page, please see its history ; for the discussion at that location, see its talk page .
UV-Visible spectrophotometer, Colorimeter, Micro-Centrifuge, Nephelometer - Turbidimeter, Flame-Photometer, Refractometer, Polarimeter, Conductivity meter, D.M. Plant, Double Cone Blender, Melting Point Apparatus, Ball Mill Apparatus, Tablet Coating Machine, Tablet Punching Machine, Tablet Hardness Tester, Tablet Counter, Dissolution Test ...
Sample preparation may involve dissolution, extraction, reaction with some chemical species, pulverizing, treatment with a chelating agent (e.g. EDTA), masking, filtering, dilution, sub-sampling or many other techniques. Treatment is done to prepare the sample into a form ready for analysis by specified analytical equipment.
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A volumetric flask (measuring flask or graduated flask) is a piece of laboratory apparatus, a type of laboratory flask, calibrated to contain a precise volume at a certain temperature. Volumetric flasks are used for precise dilutions and preparation of standard solutions. These flasks are usually pear-shaped, with a flat bottom, and made of ...
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