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The LE cell was discovered in bone marrow in 1948 by Malcolm McCallum Hargraves (1903–1982), a physician and practicing histologist at the Mayo Clinic. [5] Hargraves may have gained priority by suppressing a publication draft of John R. Haserick, who credits Dorothy Sundberg, chief hematologist at the University of Minnesota Hospitals, with ...
Noting that the invading nucleus was coated with antibody that allowed it to be ingested by a phagocytic or scavenger cell, they named the antibody that causes one cell to ingest another the LE factor and the two nuclei cell result in the LE cell. [167] The LE cell, it was determined, was a part of an anti-nuclear antibody (ANA) reaction; the ...
HeLa cells are rapidly dividing cancer cells, and the number of chromosomes varies during cancer formation and cell culture. The current estimate (excluding very tiny fragments) is a "hypertriploid chromosome number (3n+)", which means 76 to 80 total chromosomes (rather than the normal diploid number of 46) with 22–25 clonally abnormal ...
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In diagnostic pathology, a hematoxylin body, or LE body, is a dense, homogeneous, basophilic particle, easily stainable with hematoxylin. It consists of degraded nuclear material from an injured cell, along with autoantibodies and a limited amount of cytoplasm. [1] [2] [3] Hematoxylin bodies occur in systemic lupus erythematosus.
LE cell The LE cell was discovered in bone marrow in 1948 by Hargraves et al. [ 72 ] In 1957 Holborow et al. first demonstrated ANA using indirect immunofluorescence. [ 73 ] This was the first indication that processes affecting the cell nucleus were responsible for SLE.
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The cell on the left is going through mitosis and its chromosomes have condensed. Cell nucleus: A cell's information center, the cell nucleus is the most conspicuous organelle found in a eukaryotic cell. It houses the cell's chromosomes, and is the place where almost all DNA replication and RNA synthesis (transcription) occur.