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An overwhelming post-splenectomy infection (OPSI) is a rare but rapidly fatal infection occurring in individuals following removal (or permanent dysfunction) of the spleen. The infections are typically characterized by either meningitis or sepsis , and are caused by encapsulated organisms including Streptococcus pneumoniae . [ 3 ]
Normally, erythrocytes are stored and removed from the circulating blood by the spleen, including the removal of damaged erythrocytes. However, after a splenectomy the lack of presence of the spleen means this function cannot be carried out so damaged erythrocytes will continue to circulate in the blood and can release substances into the blood.
According to the Mayo Clinic, when a spleen is removed, other organs generally take over its functions, but along with the higher risk of serious infections, a patient without a spleen has ...
The most frequent cause of autosplenectomy is sickle cell anemia [10] which causes progressive splenic hypofunction over time. Increased deoxygenation causes sickling of red blood cells, which adhere to the spleen wall and splenic macrophages causing ischemia . [ 2 ]
Splenic infarction is a condition in which blood flow supply to the spleen is compromised, [1] leading to partial or complete infarction (tissue death due to oxygen shortage) in the organ. [2] Splenic infarction occurs when the splenic artery or one of its branches are occluded, for example by a blood clot .
“The family was informed that Mr. Bryan’s spleen, the root of his original symptom profile upon presentation to the hospital, was still in his body and appeared with a small cyst on its ...
Treatment-emergent central sleep apnea (TECSA), also known as complex sleep apnea, is a type of sleep apnea that typically develops when a patient starts CPAP therapy for OSA. This can occur when ...
Fever is the most common symptom of splenic abscess, followed by abdominal pain and a tender mass on palpation of the left upper quadrant of the abdomen. The common signs and symptoms described of a splenic abscess include the triad of fever, left upper quadrant tenderness, and leukocytosis is present only in one-third of the cases.