Search results
Results from the WOW.Com Content Network
NEUMA is a tool to estimate RNA abundances using length normalization, based on uniquely aligned reads and mRNA isoform models. NEUMA uses known transcriptome data available in databases like RefSeq. NOISeq NOISeq is a non-parametric approach for the identification of differentially expressed genes from count data or previously normalized count ...
DESeq2 is a software package in the field of bioinformatics and computational biology for the statistical programming language R. It is primarily employed for the analysis of high-throughput RNA sequencing (RNA-seq) data to identify differentially expressed genes between different experimental conditions.
Within computational biology, an MA plot is an application of a Bland–Altman plot for visual representation of genomic data. The plot visualizes the differences between measurements taken in two samples, by transforming the data onto M (log ratio) and A (mean average) scales, then plotting these values.
Methods: Most tools use regression or non-parametric statistics to identify differentially expressed genes, and are either based on read counts mapped to a reference genome (DESeq2, limma, edgeR) or based on read counts derived from alignment-free quantification (sleuth, [106] Cuffdiff, [107] Ballgown [108]). [109]
The function T(h, a) gives the probability of the event (X > h and 0 < Y < aX) where X and Y are independent standard normal random variables. This function can be used to calculate bivariate normal distribution probabilities [2] [3] and, from there, in the calculation of multivariate normal distribution probabilities. [4]
In statistics, a standard normal table, also called the unit normal table or Z table, [1] is a mathematical table for the values of Φ, the cumulative distribution function of the normal distribution.
To quantile normalize two or more distributions to each other, without a reference distribution, sort as before, then set to the average (usually, arithmetic mean) of the distributions. So the highest value in all cases becomes the mean of the highest values, the second highest value becomes the mean of the second highest values, and so on.
The Marsaglia polar method [1] is a pseudo-random number sampling method for generating a pair of independent standard normal random variables. [2]Standard normal random variables are frequently used in computer science, computational statistics, and in particular, in applications of the Monte Carlo method.