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  2. Ii antigen system - Wikipedia

    en.wikipedia.org/wiki/Ii_antigen_system

    The Ii antigen system is a human blood group system based upon a gene on chromosome 6 and consisting of the I antigen and the i antigen. [1] The I antigen is normally present on the cell membrane of red blood cells in all adults, while the i antigen is present in fetuses and newborns. [2]

  3. CD74 - Wikipedia

    en.wikipedia.org/wiki/CD74

    HLA class II histocompatibility antigen gamma chain also known as HLA-DR antigens-associated invariant chain or CD74 (Cluster of Differentiation 74), is a protein that in humans is encoded by the CD74 gene. [5] [6] The invariant chain (Abbreviated Ii) is a polypeptide which plays a critical role in antigen presentation.

  4. Template : Did you know nominations/Ii antigen system

    en.wikipedia.org/.../Ii_antigen_system

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  5. Antigen presentation - Wikipedia

    en.wikipedia.org/wiki/Antigen_presentation

    A non classical MHC-II molecule (HLA-DO and HLA-DM) catalyses the exchange of part of the CD74 (CLIP peptide) with the peptide antigen. Peptide-MHC-II complexes (pMHC-II) are transported to the plasma membrane and the processed antigen is presented to the helper T cells in the lymph nodes. [9]

  6. MHC class II - Wikipedia

    en.wikipedia.org/wiki/MHC_Class_II

    In some cells, antigens bind to recycled MHC class II molecules while they are in the early endosomes, while other cells such as dendritic cells internalize antigens via receptor-mediated endocytosis and create MHC class II molecules plus peptide in the endosomal-lysosomal antigen processing compartment which is independent of the synthesis of ...

  7. Immunoglobulin superfamily - Wikipedia

    en.wikipedia.org/wiki/Immunoglobulin_superfamily

    The antigen receptor of T cells is the T-cell receptor (TCR), which is composed of two chains, either the TCR-alpha and -beta chains, or the TCR-delta and gamma chains. All TCR chains contain two Ig domains in the extracellular portion; one IgV domain at the N-terminus and one IgC1 domain adjacent to the cell membrane. Antigen presenting molecules

  8. Danger model - Wikipedia

    en.wikipedia.org/wiki/Danger_model

    Function of T helper cells: Antigen-presenting cells present antigens on their Class II MHC molecules . Helper T cells recognize these by expressing the CD4 co-receptor . The activation of a resting helper T cell causes it to release cytokines and other signals (green arrows) that stimulate the activity of macrophages , killer T cells , and B ...

  9. Tetramer assay - Wikipedia

    en.wikipedia.org/wiki/Tetramer_assay

    Class II MHC molecules present extracellular antigens, allowing helper T-cells to detect bacteria, [11] fungi, and parasites. [2] Class II MHC tetramer use is becoming more common, but the tetramers are more difficult to create than class I tetramers and the bond between helper T-cells and MHC molecules is even weaker.