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Injection site reactions (ISRs) are reactions that occur at the site of injection of a drug. They may be mild or severe and may or may not require medical intervention. Some reactions may appear immediately after injection, and some may be delayed. [1] Such reactions can occur with subcutaneous, intramuscular, or intravenous administration.
Subcutaneous administration is the insertion of medications beneath the skin either by injection or infusion. A subcutaneous injection is administered as a bolus into the subcutis, the layer of skin directly below the dermis and epidermis, collectively referred to as the cutis. The instruments are usually a hypodermic needle and a syringe.
Some hematomas are visible under the surface of the skin (commonly called bruises) or possibly felt as masses or lumps. Lumps may be caused by the limitation of the blood to a sac, subcutaneous or intramuscular tissue space isolated by fascial planes. This is a key anatomical feature that helps prevent injuries from causing massive blood loss.
Gender: More bruising occurs in females due to increased subcutaneous fat. Skin tone: Discoloration caused by bruises is more prominent in lighter complexions. Diseases: Coagulation , platelet and blood vessel diseases or deficiencies can increase bruising due to more bleeding.
It can also present with telangiectasia, easy bruising, purpura, and striae. Occlusive dressings and fluorinated steroids both increase the likelihood of developing atrophy. Occlusive dressings and fluorinated steroids both increase the likelihood of developing atrophy.
The bruise depicted was produced by a subcutaneous injection. Irritation zone after injection of glatiramer acetate. Both the interferons and glatiramer acetate are available only in injectable forms, and both can cause skin reactions at the injection site, specially with subcutaneous administration.
Semaglutide injections are usually prescribed on a dose escalation scheme, meaning you start low and gradually increase your dosage. The starting dose of Wegovy is typically 0.25 milligrams, and ...
A depot injection is an injection, usually subcutaneous, intradermal, or intramuscular, that deposits a drug in a localized mass, called a depot, from which it is gradually absorbed by surrounding tissue. Such injection allows the active compound to be released in a consistent way over a long period. [26]